I will delete the previous message in the archives.
Since news sites often delete articles after so-many-days,
I have copied the information from the Epilepsy site:
Epilepsy gene identified in dogs
By Jonathan Amos BBC News science reporter
http://news.bbc.co.uk/1/hi/sci/tech/4149179.stm
Scientists have identified a faulty gene that causes epilepsy in dogs.
The finding has allowed the researchers to develop a test that could
soon help owners breed out the disease. But the discovery should
also aid the quest to understand the more severe human form of the
condition, Lafora disease, and other similar afflictions.
The latest development, reported in Science magazine, is an example of how
the human and dog genome projects are expected to benefit both species.
Researchers are comparing and contrasting the "life codes" of the two
mammals with other animals to track down the genetic causes of ill-health.
Light starter
The study in Science was produced by a Canadian/UK team led from the Hospital
for Sick Children (HSC) in Toronto. The researchers showed that the jerky
behaviour and seizures suffered by purebred miniature wirehaired dachshunds
were caused by a form of epilepsy called EPM2.
The affected dogs all share a mutation in their EPM2b gene involving multiple
repeats in the DNA code that prevent the proper production of protein.
It is thought 5% of miniature wirehaireds in the UK have the disease and
perhaps as many as 25% may be carriers of the faulty gene.
Owners usually start to notice a problem with their pets when they are about
six years old. Although incurable, the disease can be managed with a
controlled diet and drugs. "These animals will jerk in response to quite
specific things, such as sudden movement in their visual field," said Science
co-author Clare Rusbridge, a veterinary neurologist at the Stone Lion
Veterinary Centre in London.
"They also do it when there is flickering light - this is one of the
photosensitive epilepsies. One of the simplest managements is doggy sunglasses,
which means they can be walked and enjoy life," she told the BBC News website.
Relentless progression
If dogs can cope with EPM2, the same cannot be said of humans suffering
with Lafora disease. It is the most severe form of teenage-onset epilepsy.
It gets progressively worse and usually results in death within a few years
of the diagnosis.
"In terms of frequency, it is very rare but it is a horrible disease,"
said colleague Dr Berge Minassian, whose research group at the
HSC has now identified two faulty genes associated with Lafora's.
"The seizures get more and more frequent and severe, and within
a year or two they are totally uncontrollable by any means."
For dogs the benefits are more obvious. With a new test for the faulty EPM2b
gene, breed clubs could soon start a programme of controlled mating to
eradicate the disease in miniature wirehaireds and other breeds, such as
basset hounds, in which it has become amplified.
This approach is already being used in Irish setters, for example, to
tackle a blinding condition known as progressive retinal atrophy (PRA),
and an immune disorder called canine leukocyte adhesion deficiency (Clad).
Just like EPM2, both are the result of recessive mutations - a dog must have
two copies (one from each parent) of a "bad" gene to show the disease.
Familiar patterns
The UK Kennel Club is about to stop registering any Irish setter
unless it is clear of Clad.
"Because purebred dogs are highly selected - breeders choose the dams and
sires they put together - we can impose restrictions to select against
dogs that are likely to pass these genes on to future generations,"
commented Dr Jeff Sampson, the Kennel Club's canine genetics co-ordinator.
There is great hope that purebred dogs, with their large litters and
long pedigrees, will offer science the opportunity to rapidly locate
faulty genes that in humans would be far more difficult to find because
few family members may be alive to study their DNA.
"Human clinicians are increasingly turning to purebred canine populations
because these will have similar, if not identical, diseases to us and the
clinicians will identify the gene in the dog and that will then give them
a handle to start looking in human populations," explained Dr Sampson.
The Toronto hospital research group is already searching for other instances
in which the particular pattern of expanded DNA repeats seen in the
dachshunds may be driving ill-health.
"We've gone on to check the human genome as well as the genomes of cattle
and other species and have found a number of genes that contain such repeats,
and we are in the process of figuring out if they are associated with
diseases," said Dr Minassian.